clinical studies & research
While the exact biochemical mechanisms and primary targets of hydrogen are not yet fully comprehended, the therapeutic potential of hydrogen in cells, tissues, humans, animals, and even agricultural plants is gaining widespread recognition. This acknowledgment is underscored by the existence of over 500 peer-reviewed articles and a community of 1,600 researchers devoted to exploring the medical applications of hydrogen. For more information on molecular hydrogen, you can explore the following reputable scientific resources:
peer-reviewed articles & Scientific Studies:
MOLECULAR HYDROGEN & fitness + ATHLETES:
Effects of 8 days intake of hydrogen-rich water on muscular endurance performance and fatigue recovery during resistance training - PMC
https://share.google/e4DTcfKD1CtXwrhYf
Hydrogen-Rich Water to Enhance Exercise Performance: A Review of Effects and Mechanisms - PMC https://share.google/U6NzepRhrosO9RRQk
Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study https://share.google/KtJxrgDfgTe7FrEfo
Hydrogen-Rich Water Decreases Muscle Damage and Improves Power Endurance in Elite Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial - PMC https://share.google/4wJ7SY0vfhMh59JbK
Pre-Exercise Ingestion of Hydrogen-Rich Cold Water Enhances Endurance Performance and Lactate Response in Heat | MDPI https://share.google/EVMbnIsVkk62SNB1C
Recent advances in hydrogen research for exercise science: Modulating circadian rhythm, immunity, and athlete recovery - ScienceDirect https://share.google/ZjSvYrpdvB8tQns45
Hydrogen-Rich Water and Molecular Hydrogen in Sports Science: A Review of Physiological Effects, Recovery Mechanisms, and Performance Outcomes https://share.google/5Nh2kwlFfAK9IfWPX
https://brd.so/E63JBn5Tga2v5kOFRJFGzFzZReQG/kangen-athletes.pdf
Hydrogen water has exhibited potential in reducing lactic acid build-up, decreasing muscle fatigue during exercise, and potentially aiding muscle-wasting diseases.
Scientific Report | 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395574/ Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes
Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/28474871/ Effects of hydrogen rich water on prolonged intermittent exercise
Scientific Report | 3 https://pubmed.ncbi.nlm.nih.gov/25295663/ Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries
Scientific Report | 4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837388/ Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice
WEIGHT MANAGEMENT & METABOLIC
Long-term consumption of hydrogen water has been associated with fat and weight loss, resembling the effects of calorie restriction.
Scientific Report | 1 https://onlinelibrary.wiley.com/doi/10.1038/oby.2011.6 Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice
Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967957/ The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis
Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679390/ Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome
MOLECULAR HYDROGEN PDFS
Scientific Breakdown
https://brd.so/TLM2KKRGIPb3nFjG8bXlY4Ypvf67.pdf
Doctors, Scientists, Nutritionists
https://brd.so/gdAhkrIs5GDTVgbhfsxQoKOD5fOc.pdf
Return to H2
https://brd.so/E8P9gWHyFhWkqAmGi3DIc4YQ3HB8/return-to-origin--h2.pdf
Benefits of ERW (electrolyzed reduced water)
https://brd.so/xjTCpanKiYB2DVtRaMX5nJYvIIY3/benefits-of-(-)-reduced-water.pdf
Negatively Charged Water
https://brd.so/iSK9bJGZrPYs7XhDJaDsEynoilUK/healing-with-negatively-charged-water-pdf.pdf
specific CLINICAL STUDIES:
IMMUNE SYSTEM HEALTH
Scientific Report | 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376192/ Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial
Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567800/ Recent Advances in Studies of Molecular Hydrogen against Sepsis
Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560832/ Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis
Scientific Report | 4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495244/ Hydrogen: A Novel Option in Human Disease Treatment
HORMONE HEALTH
Scientific Report | 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178641/ Emerging mechanisms and novel applications of hydrogen gas therapy
Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/28560519/ Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women
Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141176/ Therapeutic Potential of Molecular Hydrogen in Metabolic Diseases from Bench to Bedside
HEALTHY INFLAMMATORY RESPONSE & ACTING AS AN ANTIOXIDANT
Scientific Report | 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871940/ Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males
Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376192/ Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial
Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988658/ Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science
Scientific Report | 4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096066/ Anti-inflammatory and antitumor action of hydrogen via reactive oxygen species
Scientific Report | 5 https://pubmed.ncbi.nlm.nih.gov/30243702/ Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress status
Scientific Report | 6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045005/ Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration
Scientific Report | 7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095341/ (2016) Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress
Scientific Report | 8 https://www.sciencedirect.com/science/article/pii/S1567576914002124?ref=pdf_download (2014) Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study
Scientific Report | 9 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563451/ (2012) Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study
Scientific Report | 10 https://www.spandidos-publications.com/10.3892/etm.2018.6880 (2018) Beneficial Effects of Hydrogen Gas Inhalation on a Murine Model of Allergic Rhinitis
COPD:
Scientific Report | 1 Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120708/
Scientific Report | 2 Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785302/
Scientific Report | 3 Hydrogen gas inhalation protects against cigarette smoke-induced COPD development in mice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051853/
Scientific Report | 4 Hydrogen Therapy may be a Novel and Effective Treatment for COPD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108576/
GUT HEALTH & DIGESTIVE ENZYME PRODUCTION
Scientific Report | 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231938/ Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679390/ Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome
Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799803/ Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota
CARDIOVASCULAR HEALTH & DISEASE TREATMENT
Scientific Report | 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600250/ A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of
OXIDATIVE STRESS
Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353690/ Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass
Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555031/ Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study
Scientific Report | 4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239052/ Hydrogen therapy as a potential therapeutic intervention in heart disease: from the past evidence to future application
HEART PROTECTION:
In diabetic mice, hydrogen water has shown significant improvements in heart health and the prevention of heart disease, holding promise as a potential intervention for diabetes-related heart issues.
Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/25979689%20 Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice
LIVER HEALTH ENHANCEMENT:
Research indicates that hydrogen water also demonstrates significant improvements in liver function and reduced oxidative stress in individuals with chronic hepatitis B.
Scientific Report | 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350887/ Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B
Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/23682614/ Effects of oral intake of hydrogen water on liver fibrogenesis in mice
Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350887/ Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B
Scientific Report | 4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196827/ A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases
Scientific Report | 5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002796/ Hydrogen treatment: a novel option in liver diseases
DIABETES:
Research suggests that hydrogen water consumption may lead to improvements in cholesterol, glucose tolerance, and insulin resistance in individuals with type 2 diabetes or prediabetes.
Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/19083400/ Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance
Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542317/ (2013) Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle
Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542317/ (2020) Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle
Scientific Report | 4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889559/ (2023) Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study
Scientific Report | 5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515190/ Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing
Scientific Report | 6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291681/ Molecular hydrogen improves type 2 diabetes through inhibiting oxidative stress
Scientific Report | 7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754517/ Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes
HYPERTENSION:
Scientific Report | 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585236/ (2022) The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial
Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692487/ Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension
Scientific Report | 3 https://pubmed.ncbi.nlm.nih.gov/30259991/ Hydrogen gas reduces chronic intermittent hypoxia-induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via the antioxidation
ANTI-INFLAMMATORY PROPERTIES:
Hydrogen water has shown promise in alleviating inflammation in rheumatoid arthritis and other conditions.
Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/23031079/ Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study
Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788323/ Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases
Scientific Report | 3 https://pubmed.ncbi.nlm.nih.gov/11510417/ Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation
ANTIOXIDANT & BRAIN PROTECTION:
Hydrogen-infused water has demonstrated antioxidant properties, potentially protecting cells from damage, including in stroke patients.
Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/17486089/ Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694409/ Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies
Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865993/ A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics
Scientific Report | 4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057981/ Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
Scientific Report | 5 https://pubmed.ncbi.nlm.nih.gov/28669654/ Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection
Scientific Report | 6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664236/ Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment
Scientific Report | 7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087877/ Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated Adolescent Mice Offspring
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.